信息来源：
http://www.natureasia.com/zh-cn/nature/highlights/86332
https://www.nature.com/nature/journal/v546/n7657/full/nature22379.html

哺乳动物细胞会选择性地从周围环境中吸收营养，以满足自身的各种需求，如增强代谢稳定性以抵御饥饿。Wilhem Palm和Craig Thompson综述了我们对哺乳动物细胞感知和获取营养策略的认识。养分平衡是内稳态和细胞增殖的一个关键特征，因此，作者探讨了转化细胞是如何利用这些代谢途径来促进癌细胞生存和生长的。

Nutrient acquisition strategies of mammalian cells

Wilhelm Palm & Craig B. Thompson

Nature 546, 234–242 (08 June 2017) doi:10.1038/nature22379

Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth-factor-induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells.